منابع مشابه
Molecular mechanical properties of short-sequence peptide enzyme mimics.
While considerable attempts have been made to recreate the high turnover rates of enzymes using synthetic enzyme mimics, most have failed and only a few have produced minimal reaction rates that can barely be considered catalytic. One particular approach we have focused on is the use of short-sequence peptides that contain key catalytic groups in close proximity. In this study, we designed six ...
متن کاملEngineered Bacterial Mimics of Human Drug Metabolizing Enzyme CYP2C9
Metabolites play a significant role in the pharmacology and toxicity of a drug. Most drugs are substrates for the hepatic P450 oxidases. Commonly, a compound is rendered less toxic, with notable exceptions. Metabolites can impose their own pharmacological, toxicological, and physiological effects, which lead to complications that have resulted in the withdrawal of several drugs from the market ...
متن کاملBase metal complexes as homogeneous catalysts and enzyme mimics.
This article is a short overview of some recent research activity in the Laboratory of Inorganic Synthesis and Catalysis (LSCI) at EPFL-ISIC. It summarizes the work on Ni-catalyzed cross-coupling reactions of non-activated alkyl halides. It then describes and discusses the work on the bio-mimetic chemistry of [Fe]-hydrogenase.
متن کاملEnzyme molecular choreography — Studies of soluble inorganic pyrophosphatases
............................................................................................................... 8 1. INTRODUCTION.................................................................................................. 9 1.1 ENZYME MECHANISMS ....................................................................................... 9 1.1.1 Kinetic mechanism and its structural interp...
متن کاملDynamic relationships between microbial biomass, respiration, inorganic nutrients and enzyme activities: informing enzyme-based decomposition models
We re-examined data from a recent litter decay study to determine if additional insights could be gained to inform decomposition modeling. Rinkes et al. (2013) conducted 14-day laboratory incubations of sugar maple (Acer saccharum) or white oak (Quercus alba) leaves, mixed with sand (0.4% organic C content) or loam (4.1% organic C). They measured microbial biomass C, carbon dioxide efflux, soil...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: ChemBioChem
سال: 2021
ISSN: 1439-4227,1439-7633
DOI: 10.1002/cbic.202100049